(S,R,S)-AHPC-Me-CO-C4-COOH

Cat. No.: HY-W998310 Purity: 99.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12 (HY-174453). PROTAC ERα Degrader-12 is a potent and highly selective ERα PROTAC degrader.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me-CO-C4-COOH Chemical Structure

CAS No. : 2349429-73-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

VHL

Molecular Weight

572.72

Formula

C₂₉H₄₀N₄O₆S

CAS No.

2349429-73-6

Appearance

Solid

Color

White to off-white

SMILES

C([C@@H](NC(CCCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (87.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7461 mL	8.7303 mL	17.4605 mL
5 mM	0.3492 mL	1.7461 mL	3.4921 mL
10 mM	0.1746 mL	0.8730 mL	1.7461 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (256 KB) HNMR (324 KB) RP-HPLC (229 KB) LCMS (340 KB)

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Targeted Degradation of the Estrogen Receptor α through Unconventional Coactivator Binding Site (CBS). J Med Chem. 2025 Jul 10;68(13):13640-13660. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7461 mL	8.7303 mL	17.4605 mL	43.6514 mL
	5 mM	0.3492 mL	1.7461 mL	3.4921 mL	8.7303 mL
	10 mM	0.1746 mL	0.8730 mL	1.7461 mL	4.3651 mL
	15 mM	0.1164 mL	0.5820 mL	1.1640 mL	2.9101 mL
	20 mM	0.0873 mL	0.4365 mL	0.8730 mL	2.1826 mL
	25 mM	0.0698 mL	0.3492 mL	0.6984 mL	1.7461 mL
	30 mM	0.0582 mL	0.2910 mL	0.5820 mL	1.4550 mL
	40 mM	0.0437 mL	0.2183 mL	0.4365 mL	1.0913 mL
	50 mM	0.0349 mL	0.1746 mL	0.3492 mL	0.8730 mL
	60 mM	0.0291 mL	0.1455 mL	0.2910 mL	0.7275 mL
	80 mM	0.0218 mL	0.1091 mL	0.2183 mL	0.5456 mL