1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-C2-PEG4-N3

(S,R,S)-AHPC-C2-PEG4-N3 (Synonyms: VH032-C2-PEG4-N3)

Cat. No.: HY-130654
Handling Instructions

(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM.

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(S,R,S)-AHPC-C2-PEG4-N3 Chemical Structure

(S,R,S)-AHPC-C2-PEG4-N3 Chemical Structure

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Description

(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM[1].

IC50 & Target[1]

VHL

 

Molecular Weight

703.85

Formula

C₃₃H₄₉N₇O₈S

SMILES

CC(C)([[email protected]](NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)C(N1C[[email protected]](O)C[[email protected]]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S,R,S)-AHPC-C2-PEG4-N3VH032-C2-PEG4-N3E3 Ligase Ligand-Linker ConjugateLigand-linkerconjugateVHLPEGPARP1Inhibitorinhibitorinhibit

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(S,R,S)-AHPC-C2-PEG4-N3
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