Thalidomide-5-O-CH2-COOH
Based on 1 Customer Validation
Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.
For research use only. We do not sell to patients.
- Purity: 95.02%
- CAS No.: 2467425-53-0
- Formula: C15H12N2O7
- Molecular Weight:332.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2467425-53-0
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Appearance Solid
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Molecular Weight 332.26
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Formula C15H12N2O7
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Color Light yellow to brown
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SMILES
O=C(O)COC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (376.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0097 mL | 15.0485 mL | 30.0969 mL | 75.2423 mL |
| 5 mM | 0.6019 mL | 3.0097 mL | 6.0194 mL | 15.0485 mL | |
| 10 mM | 0.3010 mL | 1.5048 mL | 3.0097 mL | 7.5242 mL | |
| 15 mM | 0.2006 mL | 1.0032 mL | 2.0065 mL | 5.0162 mL | |
| 20 mM | 0.1505 mL | 0.7524 mL | 1.5048 mL | 3.7621 mL | |
| 25 mM | 0.1204 mL | 0.6019 mL | 1.2039 mL | 3.0097 mL | |
| 30 mM | 0.1003 mL | 0.5016 mL | 1.0032 mL | 2.5081 mL | |
| 40 mM | 0.0752 mL | 0.3762 mL | 0.7524 mL | 1.8811 mL | |
| 50 mM | 0.0602 mL | 0.3010 mL | 0.6019 mL | 1.5048 mL | |
| 60 mM | 0.0502 mL | 0.2508 mL | 0.5016 mL | 1.2540 mL | |
| 80 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9405 mL | |
| 100 mM | 0.0301 mL | 0.1505 mL | 0.3010 mL | 0.7524 mL |
Thalidomide-5-O-CH2-COOH Related Classifications
HY-W584518 Related Classifications
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