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Cat. No.: HY-128848

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Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

Name: Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
Brand: MedChemExpress
SKU: HY-128848
Price: 60.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49)

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Based on 1 Customer Validation

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Purity: 93.92%
CAS No.: 2351103-63-2
Formula: C₃₁H₄₄N₄O₁₁
Molecular Weight:648.70

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Chemical Structure

CAS No.: 2351103-63-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

IC₅₀ & Target^[1]

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2351103-63-2
Appearance Oil
Molecular Weight 648.70
Formula C₃₁H₄₄N₄O₁₁
Color Light brown to brown
SMILES

O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCNC(COCCCCCOCCOCCCCCOCC(O)=O)=O)=CC=C3)=O
Synonyms

Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

(S,R,S)-AHPC-PEG4-N3

(S,R,S)-AHPC-PEG1-N3

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

Thalidomide-O-amido-C4-N3

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

(S,R,S)-AHPC-PEG6-C4-Cl

Thalidomide-O-amido-C4-NH2 TFA

Pomalidomide-PEG4-Ph-NH2

Thalidomide-O-amido-PEG3-C2-NH2 TFA

Thalidomide-O-amido-C8-NH2 TFA

(S,R,S)-AHPC-PEG2-N3

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

(S,R,S)-AHPC-PEG4-N3

(S,R,S)-AHPC-PEG1-N3

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

Thalidomide-O-amido-C4-N3

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

(S,R,S)-AHPC-PEG6-C4-Cl

Thalidomide-O-amido-C4-NH2 TFA

Pomalidomide-PEG4-Ph-NH2

Thalidomide-O-amido-PEG3-C2-NH2 TFA

Thalidomide-O-amido-C8-NH2 TFA

(S,R,S)-AHPC-PEG2-N3

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Related Classifications

HY-128848 Related Classifications

Bioz