2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Lenalidomide-PEG3-iodine

Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

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Lenalidomide-PEG3-iodine Chemical Structure

Lenalidomide-PEG3-iodine Chemical Structure

CAS No. : 2738934-13-7

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Lenalidomide-PEG3-iodine Related Antibodies

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Description

Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].

IC50 & Target[1]

Cereblon

 

In Vitro

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). SJF620 is a potent PROTAC BTK degrader consisting of the BTK inhibitor conjugated to Lenalidomide by a linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lenalidomide-PEG3-iodine Related Antibodies
Molecular Weight

502.30

Formula

C19H23IN2O6
CAS No.
SMILES

O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCI)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lenalidomide-PEG3-iodine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide-PEG3-iodine2738934-13-7E3 Ligase Ligand-Linker ConjugatesLenalidomidecereblonligandPEGlinkerPROTACBtkdegraderInhibitorinhibitorinhibit

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