1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Lenalidomide-PEG3-iodine

Lenalidomide-PEG3-iodine 

Cat. No.: HY-130982
Handling Instructions

Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

For research use only. We do not sell to patients.

Lenalidomide-PEG3-iodine Chemical Structure

Lenalidomide-PEG3-iodine Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugate Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].

IC50 & Target[1]

Cereblon

 

In Vitro

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). SJF620 is a potent PROTAC BTK degrader consisting of the BTK inhibitor conjugated to Lenalidomide by a linker[1].

Molecular Weight

502.30

Formula

C₁₉H₂₃IN₂O₆

SMILES

O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCI)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lenalidomide-PEG3-iodineE3 Ligase Ligand-Linker ConjugateLenalidomidecereblonligandPEGlinkerPROTACBtkdegraderInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Lenalidomide-PEG3-iodine
Cat. No.:
HY-130982
Quantity:
MCE Japan Authorized Agent: