1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. PROTAC
    Btk
  3. SJF620

SJF620 

Cat. No.: HY-133137
Handling Instructions

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

For research use only. We do not sell to patients.

SJF620 Chemical Structure

SJF620 Chemical Structure

CAS No. : 2376187-16-3

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Description

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].

IC50 & Target

Cereblon

 

In Vitro

SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in NAMALWA cells line[1].

In Vivo

SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

Molecular Weight

760.84

Formula

C₄₁H₄₄N₈O₇

CAS No.

2376187-16-3

SMILES

O=C(C(N(CC1=C2C=CC(OCCOCCOCCN3CCC(N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C7=C(N)N=CN=C74)CC3)=C1)C2=O)CC8)NC8=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SJF620SJF 620SJF-620PROTACBtkProteolysis-targeting chimeraBruton tyrosine kinaseInhibitorinhibitorinhibit

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SJF620
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