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  3. 1,2-Bis(2-iodoethoxy)ethane

1,2-Bis(2-iodoethoxy)ethane 

Cat. No.: HY-133143
Handling Instructions

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively.

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1,2-Bis(2-iodoethoxy)ethane Chemical Structure

1,2-Bis(2-iodoethoxy)ethane Chemical Structure

CAS No. : 36839-55-1

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Description

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].

IC50 & Target[1]

PEGs

 

In Vitro

1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802(HY-122562) has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1].

Molecular Weight

369.97

Formula

C₆H₁₂I₂O₂

CAS No.

36839-55-1

SMILES

ICCOCCOCCI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

1,2-Bis(2-iodoethoxy)ethanePROTAC LinkerInhibitorinhibitorinhibit

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1,2-Bis(2-iodoethoxy)ethane
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HY-133143
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