2. PROTAC
  3. PROTAC Linkers
  4. 1,2-Bis(2-iodoethoxy)ethane

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively.

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1,2-Bis(2-iodoethoxy)ethane Chemical Structure

1,2-Bis(2-iodoethoxy)ethane Chemical Structure

CAS No. : 36839-55-1

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Based on 1 publication(s) in Google Scholar

1,2-Bis(2-iodoethoxy)ethane Related Antibodies

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Description

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].

IC50 & Target[1]

PEGs

 

In Vitro

1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,2-Bis(2-iodoethoxy)ethane Related Antibodies
Molecular Weight

369.97

Formula

C6H12I2O2
CAS No.
Appearance

Liquid

Color

Light yellow to yellow

SMILES

ICCOCCOCCI
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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1,2-Bis(2-iodoethoxy)ethane Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2-Bis(2-iodoethoxy)ethane36839-55-1PROTAC LinkersInhibitorinhibitorinhibit

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