1. Antibody-drug Conjugate/ADC Related
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  3. m-PEG4-Br

m-PEG4-Br 

Cat. No.: HY-130161
Handling Instructions

m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG4-Br Chemical Structure

m-PEG4-Br Chemical Structure

CAS No. : 110429-45-3

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Description

m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target[1]

Cleavable

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

271.15

Formula

C₉H₁₉BrO₄

CAS No.

110429-45-3

SMILES

COCCOCCOCCOCCBr

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

m-PEG4-BrADC LinkerPROTAC LinkerAntibody-drug conjugates linkerADClinkerTrastuzumabMMAEInhibitorinhibitorinhibit

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m-PEG4-Br
Cat. No.:
HY-130161
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