2. PROTAC
  3. PROTAC Linkers
  4. Bromo-PEG2-bromide

Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bromo-PEG2-bromide Chemical Structure

Bromo-PEG2-bromide Chemical Structure

CAS No. : 31255-10-4

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25 mg USD 38 In-stock
50 mg USD 60 In-stock
100 mg USD 70 In-stock
250 mg USD 95 In-stock
1 g USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

Bromo-PEG2-bromide Related Antibodies

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Description

Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromo-PEG2-bromide Related Antibodies
Molecular Weight

275.97

Formula

C6H12Br2O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

BrCCOCCOCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (362.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6236 mL 18.1179 mL 36.2358 mL
5 mM 0.7247 mL 3.6236 mL 7.2472 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6236 mL 18.1179 mL 36.2358 mL 90.5896 mL
5 mM 0.7247 mL 3.6236 mL 7.2472 mL 18.1179 mL
10 mM 0.3624 mL 1.8118 mL 3.6236 mL 9.0590 mL
15 mM 0.2416 mL 1.2079 mL 2.4157 mL 6.0393 mL
20 mM 0.1812 mL 0.9059 mL 1.8118 mL 4.5295 mL
25 mM 0.1449 mL 0.7247 mL 1.4494 mL 3.6236 mL
30 mM 0.1208 mL 0.6039 mL 1.2079 mL 3.0197 mL
40 mM 0.0906 mL 0.4529 mL 0.9059 mL 2.2647 mL
50 mM 0.0725 mL 0.3624 mL 0.7247 mL 1.8118 mL
60 mM 0.0604 mL 0.3020 mL 0.6039 mL 1.5098 mL
80 mM 0.0453 mL 0.2265 mL 0.4529 mL 1.1324 mL
100 mM 0.0362 mL 0.1812 mL 0.3624 mL 0.9059 mL
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Bromo-PEG2-bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromo-PEG2-bromide31255-10-4PROTAC LinkersPROTACPEG-basedlinkerInhibitorinhibitorinhibit

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