1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. PROTAC
    Btk
  3. MT-802

MT-802 

Cat. No.: HY-122562 Purity: 98.55%
Handling Instructions

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL).

For research use only. We do not sell to patients.

MT-802 Chemical Structure

MT-802 Chemical Structure

CAS No. : 2231744-29-7

Size Price Stock Quantity
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].

IC50 & Target

DC50: 1 nM (BTK)[1].

In Vitro

MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

787.82

Formula

C₄₁H₄₁N₉O₈

CAS No.

2231744-29-7

SMILES

O=C(NC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)COCCOCCN4CCC(N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C(N)N=CN=C85)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2693 mL 6.3466 mL 12.6933 mL
5 mM 0.2539 mL 1.2693 mL 2.5387 mL
10 mM 0.1269 mL 0.6347 mL 1.2693 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MT-802MT802MT 802PROTACBtkProteolysis-targeting chimeraBruton tyrosine kinaseInhibitorinhibitorinhibit

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Product Name:
MT-802
Cat. No.:
HY-122562
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