1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. PROTAC
    Btk
  3. MT-802

MT-802 

Cat. No.: HY-122562
Handling Instructions

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL).

For research use only. We do not sell to patients.

MT-802 Chemical Structure

MT-802 Chemical Structure

CAS No. : 2231744-29-7

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Description

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].

IC50 & Target

DC50: 1 nM (BTK)[1].

In Vitro

MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].

Molecular Weight

787.82

Formula

C₄₁H₄₁N₉O₈

CAS No.

2231744-29-7

SMILES

O=C(NC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)COCCOCCN4CCC(N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C(N)N=CN=C85)CC4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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MT-802
Cat. No.:
HY-122562
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