2738934-13-7
Chemical Structure
Lenalidomide-PEG3-iodine
- CAS No.: 2738934-13-7
- Formula:C19H23IN2O6
- Molecular Weight:502.30
IUPAC Name: 3-(5-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: OTGXRHVQVDOJKI-UHFFFAOYSA-N
SMILES: O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCI)=C3
Biological Activity: Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].
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Lenalidomide-PEG3-iodine | Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. | |||||||||||||||||||||
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Keywords
