1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-NH-PEG4-Ms

Thalidomide-NH-PEG4-Ms 

Cat. No.: HY-131998
Handling Instructions

Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739.

For research use only. We do not sell to patients.

Thalidomide-NH-PEG4-Ms Chemical Structure

Thalidomide-NH-PEG4-Ms Chemical Structure

CAS No. : 2140807-24-3

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Description

Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

IC50 & Target

Cereblon

 

In Vitro

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

527.54

Formula

C₂₂H₂₉N₃O₁₀S

CAS No.

2140807-24-3

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOS(C)(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Thalidomide-NH-PEG4-MsE3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-NH-PEG4-Ms
Cat. No.:
HY-131998
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