(S,R,S)-AHPC-amido-C5-acid

Cat. No.: HY-130798 Pureza: 99.58%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180).

Para uso exclusivo en investigación. No vendemos a pacientes.

(S,R,S)-AHPC-amido-C5-acid Estructura química

No. CAS : 2162120-87-6

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 publication(s) in Google Scholar

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas E3 Ligase Ligand-Linker Conjugates:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180)^[1].

IC₅₀ & Target^[1]

VHL

Peso molecular

572.72

Fòrmula

C₂₉H₄₀N₄O₆S

No. CAS

2162120-87-6

Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H]1N(C[C@@H](C1)O)C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)=O)NCC2=CC=C(C=C2)C3=C(N=CS3)C

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (174.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7461 mL	8.7303 mL	17.4605 mL
5 mM	0.3492 mL	1.7461 mL	3.4921 mL
10 mM	0.1746 mL	0.8730 mL	1.7461 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.58%

Select Batch:

Ficha de datos (272 KB) SDS (393 KB)

COA (255 KB) HNMR (252 KB) LCMS (99 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7461 mL	8.7303 mL	17.4605 mL	43.6514 mL
	5 mM	0.3492 mL	1.7461 mL	3.4921 mL	8.7303 mL
	10 mM	0.1746 mL	0.8730 mL	1.7461 mL	4.3651 mL
	15 mM	0.1164 mL	0.5820 mL	1.1640 mL	2.9101 mL
	20 mM	0.0873 mL	0.4365 mL	0.8730 mL	2.1826 mL
	25 mM	0.0698 mL	0.3492 mL	0.6984 mL	1.7461 mL
	30 mM	0.0582 mL	0.2910 mL	0.5820 mL	1.4550 mL
	40 mM	0.0437 mL	0.2183 mL	0.4365 mL	1.0913 mL
	50 mM	0.0349 mL	0.1746 mL	0.3492 mL	0.8730 mL
	60 mM	0.0291 mL	0.1455 mL	0.2910 mL	0.7275 mL
	80 mM	0.0218 mL	0.1091 mL	0.2183 mL	0.5456 mL
	100 mM	0.0175 mL	0.0873 mL	0.1746 mL	0.4365 mL