1. PROTAC Cell Cycle/DNA Damage
  2. PROTACs CDK
  3. XY028-133

XY028-133 

Cat. No.: HY-129180
Handling Instructions

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK.

For research use only. We do not sell to patients.

XY028-133 Chemical Structure

XY028-133 Chemical Structure

CAS No. : 2229974-73-4

Size Price Stock
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 695 Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO USD 695 Ask For Quote & Lead Time
Solid
5 mg USD 360 Ask For Quote & Lead Time
10 mg USD 630 Ask For Quote & Lead Time
25 mg USD 1100 Ask For Quote & Lead Time
50 mg USD 1900 Ask For Quote & Lead Time
100 mg USD 3300 Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Description

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK[1].

IC50 & Target[1]

CDK4

 

CDK6

 

In Vitro

XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1002.23

Formula

C53H67N11O7S

CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O)=O)=O)C[C@H](O)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9978 mL 4.9889 mL 9.9778 mL
5 mM 0.1996 mL 0.9978 mL 1.9955 mL
10 mM 0.0998 mL 0.4989 mL 0.9978 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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XY028-133 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
XY028-133
Cat. No.:
HY-129180
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