1. PROTAC Cell Cycle/DNA Damage
  2. PROTACs CDK
  3. XY028-133

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK.

For research use only. We do not sell to patients.

XY028-133 Chemical Structure

XY028-133 Chemical Structure

CAS No. : 2229974-73-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 695 In-stock
Solution
10 mM * 1 mL in DMSO USD 695 In-stock
Solid
5 mg USD 360 In-stock
10 mg USD 630 In-stock
25 mg USD 1100 In-stock
50 mg USD 1900 In-stock
100 mg USD 3300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK[1].

IC50 & Target[1]

CDK4

 

CDK6

 

In Vitro

XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1002.23

Formula

C53H67N11O7S

CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O)=O)=O)C[C@H](O)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (49.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9978 mL 4.9889 mL 9.9778 mL
5 mM 0.1996 mL 0.9978 mL 1.9955 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9978 mL 4.9889 mL 9.9777 mL 24.9444 mL
5 mM 0.1996 mL 0.9978 mL 1.9955 mL 4.9889 mL
10 mM 0.0998 mL 0.4989 mL 0.9978 mL 2.4944 mL
15 mM 0.0665 mL 0.3326 mL 0.6652 mL 1.6630 mL
20 mM 0.0499 mL 0.2494 mL 0.4989 mL 1.2472 mL
25 mM 0.0399 mL 0.1996 mL 0.3991 mL 0.9978 mL
30 mM 0.0333 mL 0.1663 mL 0.3326 mL 0.8315 mL
40 mM 0.0249 mL 0.1247 mL 0.2494 mL 0.6236 mL
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XY028-133 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
XY028-133
Cat. No.:
HY-129180
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