XY028-133
Based on 1 Customer Validation
XY028-133 is a selective CDK4/6 PROTAC degrader. XY028-133 targets and ubiquitinates CDK4/6 for degradation by binding to the VHL E3 ubiquitin ligase. XY028-133 can be used for research related to melanoma.
(Pink: CDK4 and CDK6 ligand (HY-50767); Blue: VHL ligand (HY-125845); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 2229974-73-4
- Formula: C53H67N11O7S
- Molecular Weight:1002.23
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
CDK4 |
CDK6 |
In Vitro
Chemical Information
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CAS No. 2229974-73-4
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Appearance Solid
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Molecular Weight 1002.23
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Formula C53H67N11O7S
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Color Light yellow to green yellow
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SMILES
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O)=O)=O)C[C@H](O)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (49.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9978 mL | 4.9889 mL | 9.9777 mL | 24.9444 mL |
| 5 mM | 0.1996 mL | 0.9978 mL | 1.9955 mL | 4.9889 mL | |
| 10 mM | 0.0998 mL | 0.4989 mL | 0.9978 mL | 2.4944 mL | |
| 15 mM | 0.0665 mL | 0.3326 mL | 0.6652 mL | 1.6630 mL | |
| 20 mM | 0.0499 mL | 0.2494 mL | 0.4989 mL | 1.2472 mL | |
| 25 mM | 0.0399 mL | 0.1996 mL | 0.3991 mL | 0.9978 mL | |
| 30 mM | 0.0333 mL | 0.1663 mL | 0.3326 mL | 0.8315 mL | |
| 40 mM | 0.0249 mL | 0.1247 mL | 0.2494 mL | 0.6236 mL |
XY028-133 Related Classifications
HY-129180 Related Classifications
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