1. PROTAC
    Cell Cycle/DNA Damage
  2. PROTACs
    CDK
  3. XY028-133

XY028-133 

Cat. No.: HY-129180 Purity: 98.03%
Handling Instructions

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK.

For research use only. We do not sell to patients.

XY028-133 Chemical Structure

XY028-133 Chemical Structure

CAS No. : 2229974-73-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 882 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 882 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK[1].

IC50 & Target[1]

CDK4

 

CDK6

 

In Vitro

XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1002.23

Formula

C₅₃H₆₇N₁₁O₇S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9978 mL 4.9889 mL 9.9778 mL
5 mM 0.1996 mL 0.9978 mL 1.9955 mL
10 mM 0.0998 mL 0.4989 mL 0.9978 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
XY028-133
Cat. No.:
HY-129180
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