2229974-73-4
Chemical Structure
XY028-133
- CAS No.: 2229974-73-4
- Formula:C53H67N11O7S
- Molecular Weight:1002.23
IUPAC Name: (2S,4R)-1-((S)-2-(7-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: MWVNDEBEHBRZEC-WWTLGBROSA-N
SMILES: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O)=O)=O)C[C@H](O)C3
Biological Activity: XY028-133 is a selective CDK4/6 PROTAC degrader. XY028-133 targets and ubiquitinates CDK4/6 for degradation by binding to the VHL E3 ubiquitin ligase. XY028-133 can be used for research related to melanoma[1].
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XY028-133 | 99.07% | XY028-133 is a selective CDK4/6 PROTAC degrader. XY028-133 targets and ubiquitinates CDK4/6 for degradation by binding to the VHL E3 ubiquitin ligase. XY028-133 can be used for research related to melanoma. | ||||||||||||||||||||
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