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Cat. No.: HY-181231

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PROTAC CDK9 degrader-12

PROTAC CDK9 degrader-12 is a selective CDK9 PROTAC degrader with a DC₅₀ of 23 nM. PROTAC CDK9 degrader-12 induces proteasome-dependent degradation of CDK9, blocks CDK9-mediated HIV-1 transcriptional elongation, and reduces HIV-1 RNA synthesis. PROTAC CDK9 degrader-12 is applicable to research related to HIV-1 infection.
(Pink: CDK9 ligand (HY-181275); Blue: VHL ligand (HY-120217); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3052648-82-2
Formula: C₆₀H₈₂N₁₄O₇S₂
Molecular Weight:1175.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PROTAC CDK9 degrader-12 Chemical Structure

CAS No.: 3052648-82-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC CDK9 degrader-12 is a selective CDK9 PROTAC degrader with a DC₅₀ of 23 nM. PROTAC CDK9 degrader-12 induces proteasome-dependent degradation of CDK9, blocks CDK9-mediated HIV-1 transcriptional elongation, and reduces HIV-1 RNA synthesis. PROTAC CDK9 degrader-12 is applicable to research related to HIV-1 infection^[1]. (Pink: CDK9 ligand (HY-181275); Blue: VHL ligand (HY-120217); Black: linker).

IC₅₀ & Target^[1]

CDK9

23 nM ()

VHL

All PROTACs Isoforms :

All CDK Isoforms :

All HIV Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

PROTAC CDK9 degrader-12 (1.0 μM, unspecified serial dilutions; variable times) potently inhibits HIV-1 replication in SupT1 cells (IC₅₀ = 78.92 nM) with a high selectivity index (531), acting by blocking CDK9-mediated HIV-1 transcription elongation, and its anti-HIV-1 activity is dependent on wild-type CDK9 degradation^[1].
PROTAC CDK9 degrader-12 (10 μM; 24 h) exhibits no obvious cytotoxicity in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3052648-82-2
Molecular Weight 1175.51
Formula C₆₀H₈₂N₁₄O₇S₂
SMILES

CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCCCCCN4N=NC(CN5CCN(S(=O)(C6=CC=C(NC7=NC8=C(C=N7)C=C(C(N(C)C)=O)N8C9CCCC9)C=C6)=O)CC5)=C4)=O)C(C)(C)C)=O)=O)C=C2)SC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang B, et al. A potent and selective PROTAC degrader of CDK9 as effective inhibitor of HIV-1 RNA synthesis. Mol Divers. Published online November 12, 2025. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC CDK9 degrader-12

All PROTACs Isoforms

All CDK Isoforms

All HIV Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC CDK9 degrader-12 Related Classifications

HY-181231 Related Classifications