2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. E3 ligase Ligand 63-N-CH2-Ph-O-CH3

E3 ligase Ligand 63-N-CH2-Ph-O-CH3 is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

For research use only. We do not sell to patients.

E3 ligase Ligand 63-N-CH2-Ph-O-CH3

E3 ligase Ligand 63-N-CH2-Ph-O-CH3 Chemical Structure

CAS No. : 2357109-91-0

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E3 ligase Ligand 63-N-CH2-Ph-O-CH3 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

E3 ligase Ligand 63-N-CH2-Ph-O-CH3 is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E3 ligase Ligand 63-N-CH2-Ph-O-CH3 Related Antibodies
Molecular Weight

458.31

Formula

C21H20BrN3O4
CAS No.
Appearance

Solid

Color

Yellow to green

SMILES

O=C1N(C=2C(Br)=CC=CC2N1C3C(=O)N(C(=O)CC3)CC4=CC=C(OC)C=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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E3 ligase Ligand 63-N-CH2-Ph-O-CH3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand 63-N-CH2-Ph-O-CH32357109-91-0E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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E3 ligase Ligand 63-N-CH2-Ph-O-CH3
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