1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. (S,R,S)-AHPC-C4-NH2

(S,R,S)-AHPC-C4-NH2  (Synonyms: VH032-C4-NH2)

Cat. No.: HY-114176A
Handling Instructions

(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form ((S,R,S)-AHPC-C4-NH2 dihydrochloride and (S,R,S)-AHPC-C4-NH2 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C4-NH2 Chemical Structure

(S,R,S)-AHPC-C4-NH2 Chemical Structure

CAS No. : 2138439-53-7

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Description

(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].

IC50 & Target

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

529.69

Formula

C27H39N5O4S

CAS No.
SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCN)=O)=O)C[C@H](O)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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(S,R,S)-AHPC-C4-NH2 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(S,R,S)-AHPC-C4-NH2
Cat. No.:
HY-114176A
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