2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-PEG6-butyl iodide

Pomalidomide-PEG6-butyl iodide 

Cat. No.: HY-136156 Purity: 98.35%
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Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG6-butyl iodide Chemical Structure

Pomalidomide-PEG6-butyl iodide Chemical Structure

CAS No. : 1835705-74-2

Size Price Stock Quantity
25 mg USD 305 In-stock
50 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Pomalidomide-PEG6-butyl iodide Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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  • Purity & Documentation

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Description

Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-PEG6-butyl iodide Related Antibodies
Molecular Weight

761.60

Formula

C31H44IN3O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCOCCOCCOCCCCCCI
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (131.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3130 mL 6.5651 mL 13.1303 mL
5 mM 0.2626 mL 1.3130 mL 2.6261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3130 mL 6.5651 mL 13.1303 mL 32.8256 mL
5 mM 0.2626 mL 1.3130 mL 2.6261 mL 6.5651 mL
10 mM 0.1313 mL 0.6565 mL 1.3130 mL 3.2826 mL
15 mM 0.0875 mL 0.4377 mL 0.8754 mL 2.1884 mL
20 mM 0.0657 mL 0.3283 mL 0.6565 mL 1.6413 mL
25 mM 0.0525 mL 0.2626 mL 0.5252 mL 1.3130 mL
30 mM 0.0438 mL 0.2188 mL 0.4377 mL 1.0942 mL
40 mM 0.0328 mL 0.1641 mL 0.3283 mL 0.8206 mL
50 mM 0.0263 mL 0.1313 mL 0.2626 mL 0.6565 mL
60 mM 0.0219 mL 0.1094 mL 0.2188 mL 0.5471 mL
80 mM 0.0164 mL 0.0821 mL 0.1641 mL 0.4103 mL
100 mM 0.0131 mL 0.0657 mL 0.1313 mL 0.3283 mL
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Pomalidomide-PEG6-butyl iodide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG6-butyl1835705-74-2E3 Ligase Ligand-Linker ConjugatesE3ligasecereblonPROTACInhibitorinhibitorinhibit

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