1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-PEG2-COOH

Pomalidomide-PEG2-COOH (Synonyms: Pomalidomide 4'-PEG2-acid)

Cat. No.: HY-131872
Handling Instructions

Pomalidomide-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG2-COOH Chemical Structure

Pomalidomide-PEG2-COOH Chemical Structure

CAS No. : 2140807-17-4

Size Price Stock Quantity
25 mg USD 158 In-stock
Estimated Time of Arrival: December 31
50 mg USD 320 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Pomalidomide-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

Molecular Weight

433.41

Formula

C₂₀H₂₃N₃O₈

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (576.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3073 mL 11.5364 mL 23.0728 mL
5 mM 0.4615 mL 2.3073 mL 4.6146 mL
10 mM 0.2307 mL 1.1536 mL 2.3073 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Pomalidomide-PEG2-COOH
Cat. No.:
HY-131872
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