Thalidomide-azetidine-C-OH
Based on 1 Customer Validation
Thalidomide-azetidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
For research use only. We do not sell to patients.
- Purity: 98.53%
- CAS No.: 2241314-93-0
- Formula: C17H17N3O5
- Molecular Weight:343.34
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
-
Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
|
Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2241314-93-0
-
Appearance Solid
-
Molecular Weight 343.34
-
Formula C17H17N3O5
-
Color Light yellow to yellow
-
SMILES
O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CC(CO)C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (145.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (242 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9126 mL | 14.5628 mL | 29.1256 mL | 72.8141 mL |
| 5 mM | 0.5825 mL | 2.9126 mL | 5.8251 mL | 14.5628 mL | |
| 10 mM | 0.2913 mL | 1.4563 mL | 2.9126 mL | 7.2814 mL | |
| 15 mM | 0.1942 mL | 0.9709 mL | 1.9417 mL | 4.8543 mL | |
| 20 mM | 0.1456 mL | 0.7281 mL | 1.4563 mL | 3.6407 mL | |
| 25 mM | 0.1165 mL | 0.5825 mL | 1.1650 mL | 2.9126 mL | |
| 30 mM | 0.0971 mL | 0.4854 mL | 0.9709 mL | 2.4271 mL | |
| 40 mM | 0.0728 mL | 0.3641 mL | 0.7281 mL | 1.8204 mL | |
| 50 mM | 0.0583 mL | 0.2913 mL | 0.5825 mL | 1.4563 mL | |
| 60 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2136 mL | |
| 80 mM | 0.0364 mL | 0.1820 mL | 0.3641 mL | 0.9102 mL | |
| 100 mM | 0.0291 mL | 0.1456 mL | 0.2913 mL | 0.7281 mL |
Thalidomide-azetidine-C-OH Related Classifications
HY-W998240 Related Classifications
Powered by Bioz