2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. CRBN ligand-900 Gly

CRBN ligand-900 Gly is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a CRBN ligand and a linker. CRBN ligand-900 Gly can be connected to the target protein ligand to form a PROTAC NTRK1 degrader-1 (HY-181052).

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CRBN ligand-900 Gly

CRBN ligand-900 Gly Estructura química

No. CAS : 2922276-95-5

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CRBN ligand-900 Gly Related Antibodies

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Descripciòn

CRBN ligand-900 Gly is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a CRBN ligand and a linker. CRBN ligand-900 Gly can be connected to the target protein ligand to form a PROTAC NTRK1 degrader-1 (HY-181052)[1].

IC50 & Target[1]

Cereblon

 

In Vitro

A PROTAC consists of two distinct ligands linked by a linker: one is a ligand for an E3 ubiquitin ligase, and the other is a ligand for a target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-900 Gly Related Antibodies
Peso molecular

345.40

Fòrmula

C17H23N5O3
No. CAS
SMILES

NCC(N1CCN(C2=CC=C(NC3CCC(NC3=O)=O)C=C2)CC1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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CRBN ligand-900 Gly Related Classifications

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Keywords:

CRBN ligand-900 Gly2922276-95-5E3 Ligase Ligand-Linker ConjugatesNTRK1 G595Rproteasomal degradation293 T cellsubiquitinationNTRK1 F598LcereblonNTRK1 wild-typeNTRK1 G667CNTRK1 kinase activitymiceInhibitorinhibitorinhibit

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Nombre del producto:
CRBN ligand-900 Gly
Cat. No.:
HY-185546
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