PROTAC NTRK1 degrader-1 

PROTAC NTRK1 degrader-1 is a wild-type and mutant NTRK1 PROTAC degrader with IC₅₀ values of 4 nM (wild-type), 2 nM (G595R), 5 nM (G667C), and <0.5 nM (F598L). PROTAC NTRK1 degrader-1 catalyzes ubiquitination and subsequent proteasome-mediated degradation of wild-type and mutant (G595R, G667C, F598L) NTRK1. PROTAC NTRK1 degrader-1 can be used for the research of solid tumors^[1]. (Pink: NTRK1 ligand (HY-185545); Blue: Cereblon ligand (HY-W1115186); Black: linker).

NTRK degrader-1 (compound 5b) (6 h) degrades wild-type NTRK1, NTRK1^G595R, NTRK1^G667C, and NTRK1^F598L in 293 T cells at 6 h, with the IP (inflection point) values of 0.2 nM, 1 nM, 2 nM, and 0.2 nM, respectively^[1].
NTRK degrader-1 inhibits wild-type NTRK1, NTRK1^G595R, NTRK1^G667C, and NTRK1^F598L with IC₅₀ values of 4 nM, 2 nM, 5 nM and <0.5 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

746.75

C₃₈H₃₅FN₁₀O₆

2922274-35-7

O=C1NC(C=CC(C(NCC(N2CCN(C3=CC=C(NC4CCC(NC4=O)=O)C=C3)CC2)=O)=O)=C5)=C5OC(C=CC(F)=C6)=C6CNC7=NC8=C1C=NN8C=C7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Anderson C, et al. Design, synthesis and biological evaluation of macrocyclic NTRK heterobifunctional degraders. Bioorg Med Chem Lett. 2026;133:130516.  [Content Brief]