Trk Receptor Inhibitors

TrkA

TrkB

TrkC

Trk

Trk Receptor Inhibitors, Agonists, Antagonists & Activators

Product Name	TrkA	TrkB	TrkC	Trk	Purity
Larotrectinib	TrkA	TrkB	TrkC		99.95%
ANA-12		TrkB			99.91%
7,8-Dihydroxyflavone		TrkB			99.90%
Repotrectinib	TrkA				99.90%
Sitravatinib	TrkA, IC₅₀: 5 nM	TrkB, IC₅₀: 9 nM			99.59%
Amitriptyline hydrochloride	TrkA	TrkB			98.91%
GW 441756	TrkA, IC₅₀: 2 nM				99.95%
GNF-5837	TrkA, IC₅₀: 11 nM	TrkB, IC₅₀: 9 nM	TrkC, IC₅₀: 7 nM		99.65%
N-Acetyl-5-hydroxytryptamine		TrkB			99.96%
Lestaurtinib	TrkA, IC₅₀: 25 nM				99.17%
Selitrectinib	TrkA, IC₅₀: 0.6 nM		TrkC, IC₅₀: <2.5 nM		99.90%
LM22B-10		TrkB	TrkC		99.92%
Larotrectinib sulfate	TrkA	TrkB	TrkC		98.96%
Altiratinib	Trk1, IC₅₀: 0.85 nM	Trk2, IC₅₀: 4.6 nM	Trk3, IC₅₀: 0.93 nM		98.05%
AZ-23	TrkA, IC₅₀: 2 nM	TrkB, IC₅₀: 8 nM			98.57%
Cyclotraxin B		TrkB			98.01%
Tamnorzatinib	TrkA				98.07%
Tyrphostin AG 879	TrkA				99.85%
DS-1205b free base	TrkA, IC₅₀: 407 nM				99.92%
TrkA-IN-1	TrkA, IC₅₀: 99 nM	TrkB, IC₅₀: 81 μM	TrkC, IC₅₀: 25 μM		98.03%
PF-6683324	TrkA, IC₅₀: 1.9 nM (in cell-based assays)	TrkB, IC₅₀: 2.6 nM (in cell-based assays)	TrkC, IC₅₀: 1.1 nM (in cell-based assays)		99.41%
CH7057288				TRK	98.68%
Paltimatrectinib	TrkA				99.96%
CE-245677	TrkA				98.14%
TrkA-IN-3	TrkA, IC₅₀: 22.4 nM				98.46%
PF-06273340				TRK	≥98.0%
PF-06737007	TrkA, IC₅₀: 7.7 nM (in cell-based assays)	TrkB, IC₅₀: 15 nM (in cell-based assays)	TrkC, IC₅₀: 3.9 nM (in cell-based assays)		99.70%
Sitravatinib malate	TrkA, IC₅₀: 5 nM	TrkB, IC₅₀: 9 nM
LPM4870108	TrkA, IC₅₀: 2.4 nM		TrkC, IC₅₀: 0.2 nM
FLT3/TrKA-IN-1	TrkA, IC₅₀: 23.6 nM
PF-06733804	TrkA, IC₅₀: 8.4 nM (in cell-based assays)	TrkB, IC₅₀: 6.2 nM (in cell-based assays)	TrkC, IC₅₀: 2.2 nM (in cell-based assays)
Trk-IN-7	TrkA, IC₅₀: <25 nM	TrkB, IC₅₀: <5 nM	TrkC, IC₅₀: <25 nM
TrkA-IN-4	TrkA				99.90%
Trk-IN-8	TrkA		TrkC
Amitriptyline hydrochloride (Standard)	TrkA	TrkB
Trk-IN-20	TrkA, IC₅₀: 1.6 nM	TrkB, IC₅₀: 2.9 nM	TrkC, IC₅₀: 2.0 nM
TRK-IN-23	TrkA, IC₅₀: 0.5 nM TRKA^G595R, IC₅₀: 14 nM TRKA^F589L, IC₅₀: 4.4 nM TRKA^G667C, IC₅₀: 4.8 nM		TrkC, IC₅₀: 9 nM
TIY-7	TrkA, IC₅₀: 2.9 nM
Cyclotraxin B TFA		TrkB
Protein kinase inhibitor 5 sulfate hydrate	TrkA, IC₅₀: 1.8 nM
Protein kinase inhibitor 5	TrkA, IC₅₀: 1.8 nM
Trk-IN-11	TrkA
(R)-Larotrectinib	TrkA, IC₅₀: 28.5 nM
TrkB-IN-1		TrkB
CZS-241	TrkA, IC₅₀: 2.74 μM
Trk-IN-10	TrkA
TRK II-IN-1	TrkA, IC₅₀: 3.3 nM	TrkB, IC₅₀: 6.4 nM	TrkC, IC₅₀: 4.3 nM
Multi-kinase-IN-6	TrkA, IC₅₀: 0.33 μM
Pan-Trk-IN-3	TrkA, IC₅₀: 2 nM	TrkB, IC₅₀: 3 nM	TrkC, IC₅₀: 2 nM
Type II TRK inhibitor 1	TrkA		TrkC
D5261	TrkA
IHMT-TRK-284	TrkA, IC₅₀: 10.5 nM	TrkB, IC₅₀: 0.7 nM	TrkC, IC₅₀: 2.6 nM
Anizatrectinib	TrkA

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