1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. VHL Ligand-Linker Conjugates 17

VHL Ligand-Linker Conjugates 17 

Cat. No.: HY-133046
Handling Instructions

VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader.

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VHL Ligand-Linker Conjugates 17 Chemical Structure

VHL Ligand-Linker Conjugates 17 Chemical Structure

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Description

VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader[1].

IC50 & Target[1]

VHL

 

Molecular Weight

654.75

Formula

C₃₇H₄₂N₄O₇

SMILES

O=C(C[[email protected]@H](C1=CC=CC=C1)NC([[email protected]]2N(C([[email protected]](C(C)C)C3=CC(C)=NO3)=O)C[[email protected]](O)C2)=O)N(CC4)CCC4C#CC5=CC=C(C(O)=O)C=C5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VHL Ligand-Linker Conjugates 17E3 Ligase Ligand-Linker ConjugateVHLligandARD-266androgenreceptorlinkerE3ubiquitinligaseInhibitorinhibitorinhibit

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VHL Ligand-Linker Conjugates 17
Cat. No.:
HY-133046
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