1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-NH-PEG2-C2-NH-Boc

Thalidomide-NH-PEG2-C2-NH-Boc 

Cat. No.: HY-130853 Purity: 98.17%
Handling Instructions

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology.

For research use only. We do not sell to patients.

Thalidomide-NH-PEG2-C2-NH-Boc Chemical Structure

Thalidomide-NH-PEG2-C2-NH-Boc Chemical Structure

CAS No. : 2097509-40-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
250 mg USD 300 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugate Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

dBRD9 (0-1 μM) exerts a potent anti-proliferative effect, exceeding non-degrading probe potencies in excesses of 10 to 100 fold[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

504.53

Formula

C₂₄H₃₂N₄O₈

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Thalidomide-NH-PEG2-C2-NH-Boc
Cat. No.:
HY-130853
Quantity:
MCE Japan Authorized Agent: