1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-NH-PEG2-C2-NH-Boc

Thalidomide-NH-PEG2-C2-NH-Boc 

Cat. No.: HY-130853
Handling Instructions

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology.

For research use only. We do not sell to patients.

Thalidomide-NH-PEG2-C2-NH-Boc Chemical Structure

Thalidomide-NH-PEG2-C2-NH-Boc Chemical Structure

CAS No. : 2097509-40-3

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Description

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].

In Vitro

dBRD9 (0-1 μM) exerts a potent anti-proliferative effect, exceeding non-degrading probe potencies in excesses of 10 to 100 fold[1].

Molecular Weight

504.53

Formula

C₂₄H₃₂N₄O₈

CAS No.

2097509-40-3

SMILES

O=C(OC(C)(C)C)NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Thalidomide-NH-PEG2-C2-NH-BocE3 Ligase Ligand-Linker ConjugateCancerProtein DegradationDrug DesignBromodomainEpigenetics AMLEOL-1MOLM-13MV4;11Inhibitorinhibitorinhibit

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Product name:
Thalidomide-NH-PEG2-C2-NH-Boc
Cat. No.:
HY-130853
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