(S,R,S)-AHPC-C8-NH2 dihydrochloride
(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1.
For research use only. We do not sell to patients.
- CAS No.: 2341796-80-1
- Formula: C31H49Cl2N5O4S
- Molecular Weight:658.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Thalidomide-O-amido-C6-NH2 hydrochloride -
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Pomalidomide-PEG2-COOH -
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Pomalidomide-PEG3-C2-NH2 hydrochloride -
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Thalidomide-O-amido-C4-NH2 hydrochloride -
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Pomalidomide-PEG4-COOH -
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Pomalidomide 4'-PEG5-acid -
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Thalidomide-4-O-C6-NH2 hydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VHL |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2341796-80-1
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Molecular Weight 658.72
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Formula C31H49Cl2N5O4S
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SMILES
[H]Cl.[H]Cl.O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCN)=O
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Synonyms
VH032-C8-NH2 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S,R,S)-AHPC-C8-NH2 dihydrochloride Related Classifications
HY-133487 Related Classifications
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