1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-C8-NH2 dihydrochloride

(S,R,S)-AHPC-C8-NH2 dihydrochloride (Synonyms: VH032-C8-NH2 dihydrochloride)

Cat. No.: HY-133487
Handling Instructions

(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C8-NH2 dihydrochloride Chemical Structure

(S,R,S)-AHPC-C8-NH2 dihydrochloride Chemical Structure

CAS No. : 2341796-80-1

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Description

(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

658.72

Formula

C₃₁H₄₉Cl₂N₅O₄S

CAS No.

2341796-80-1

SMILES

[H]Cl.[H]Cl.O=C(N(C[[email protected]](O)C1)[[email protected]@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[[email protected]](C(C)(C)C)NC(CCCCCCCCN)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

(S,R,S)-AHPC-C8-NH2VH032-C8-NH2E3 Ligase Ligand-Linker ConjugateAKTdegradationXF038-161APROTACrheumatoid arthritisosteoarthritisCrohn’sdiseaseangiofibromaretinalvascularizationdiabetic retinopathyInhibitorinhibitorinhibit

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Product Name:
(S,R,S)-AHPC-C8-NH2 dihydrochloride
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HY-133487
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