1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Pomalidomide-PEG4-C2-NH2 hydrochloride

Pomalidomide-PEG4-C2-NH2 hydrochloride 

Cat. No.: HY-112599B
Handling Instructions

Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs..

For research use only. We do not sell to patients.

Pomalidomide-PEG4-C2-NH2 hydrochloride Chemical Structure

Pomalidomide-PEG4-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2357105-92-9

Size Price Stock Quantity
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs..

IC50 & Target

Cereblon

 

Molecular Weight

528.98

Formula

C23H33ClN4O8

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 220 mg/mL (415.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8904 mL 9.4522 mL 18.9043 mL
5 mM 0.3781 mL 1.8904 mL 3.7809 mL
10 mM 0.1890 mL 0.9452 mL 1.8904 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5.5 mg/mL (10.40 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5.5 mg/mL (10.40 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Pomalidomide-PEG4-C2-NH2 hydrochloride
Cat. No.:
HY-112599B
Quantity:
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