Pomalidomide-PEG4-C2-NH2 hydrochloride

Name: Pomalidomide-PEG4-C2-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-112599B
Rating: 4.5 (1 reviews)

Cat. No.: HY-112599B Purity: 99.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs..

For research use only. We do not sell to patients.

Pomalidomide-PEG4-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2357105-92-9

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 1950	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-PEG4-C2-NH2 hydrochloride:

Pomalidomide-PEG4-C2-NH2 Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Cereblon

Molecular Weight

528.98

Formula

C₂₃H₃₃ClN₄O₈

CAS No.

2357105-92-9

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 220 mg/mL (415.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (189.04 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8904 mL	9.4522 mL	18.9043 mL
5 mM	0.3781 mL	1.8904 mL	3.7809 mL
10 mM	0.1890 mL	0.9452 mL	1.8904 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5.5 mg/mL (10.40 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 5.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (55.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 5.5 mg/mL (10.40 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 5.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (55.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (245 KB) HNMR (168 KB) LCMS (129 KB)

Handling Instructions (2659 KB)

References

[1]. Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer. WO2018081530A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.8904 mL	9.4522 mL	18.9043 mL	47.2608 mL
	5 mM	0.3781 mL	1.8904 mL	3.7809 mL	9.4522 mL
	10 mM	0.1890 mL	0.9452 mL	1.8904 mL	4.7261 mL
	15 mM	0.1260 mL	0.6301 mL	1.2603 mL	3.1507 mL
	20 mM	0.0945 mL	0.4726 mL	0.9452 mL	2.3630 mL
	25 mM	0.0756 mL	0.3781 mL	0.7562 mL	1.8904 mL
	30 mM	0.0630 mL	0.3151 mL	0.6301 mL	1.5754 mL
	40 mM	0.0473 mL	0.2363 mL	0.4726 mL	1.1815 mL
	50 mM	0.0378 mL	0.1890 mL	0.3781 mL	0.9452 mL
	60 mM	0.0315 mL	0.1575 mL	0.3151 mL	0.7877 mL
	80 mM	0.0236 mL	0.1182 mL	0.2363 mL	0.5908 mL
	100 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4726 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.