2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-PEG2-C2-NH2 TFA

Thalidomide-PEG2-C2-NH2 TFA  (Synonyms: Thalidomide-NH-PEG2-C2-NH2 TFA)

Cat. No.: HY-129703A Purity: 99.39%
COA Handling Instructions

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Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-PEG2-C2-NH2 TFA Chemical Structure

Thalidomide-PEG2-C2-NH2 TFA Chemical Structure

CAS No. : 2097509-36-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-PEG2-C2-NH2 TFA:

Thalidomide-PEG2-C2-NH2 TFA Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-PEG2-C2-NH2 TFA Related Antibodies
Molecular Weight

518.44

Formula

C21H25F3N4O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN)=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (192.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9289 mL 9.6443 mL 19.2886 mL
5 mM 0.3858 mL 1.9289 mL 3.8577 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.39%

COA (250 KB) RP-HPLC (206 KB) LCMS (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9289 mL 9.6443 mL 19.2886 mL 48.2216 mL
5 mM 0.3858 mL 1.9289 mL 3.8577 mL 9.6443 mL
10 mM 0.1929 mL 0.9644 mL 1.9289 mL 4.8222 mL
15 mM 0.1286 mL 0.6430 mL 1.2859 mL 3.2148 mL
20 mM 0.0964 mL 0.4822 mL 0.9644 mL 2.4111 mL
25 mM 0.0772 mL 0.3858 mL 0.7715 mL 1.9289 mL
30 mM 0.0643 mL 0.3215 mL 0.6430 mL 1.6074 mL
40 mM 0.0482 mL 0.2411 mL 0.4822 mL 1.2055 mL
50 mM 0.0386 mL 0.1929 mL 0.3858 mL 0.9644 mL
60 mM 0.0321 mL 0.1607 mL 0.3215 mL 0.8037 mL
80 mM 0.0241 mL 0.1206 mL 0.2411 mL 0.6028 mL
100 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.4822 mL
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Thalidomide-PEG2-C2-NH2 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-PEG2-C2-NH22097509-36-7Thalidomide-NH-PEG2-C2-NH2E3 Ligase Ligand-Linker ConjugatesE3ligaseligand-linkerconjugatePEG3PROTACInhibitorinhibitorinhibit

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