Thalidomide-PEG2-C2-NH2 TFA
Based on 1 Customer Validation
Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
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- Pureté : 99.13%
- CAS No.: 2097509-36-7
- Formule: C21H25F3N4O8
- Masse moléculaire:518.44
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Stockage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2097509-36-7
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Appearance Solid
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Masse moléculaire 518.44
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Formule C21H25F3N4O8
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Color Light yellow to yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN)=O.O=C(O)C(F)(F)F
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Synonyms
Thalidomide-NH-PEG2-C2-NH2 TFA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (192.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9289 mL | 9.6443 mL | 19.2886 mL | 48.2216 mL |
| 5 mM | 0.3858 mL | 1.9289 mL | 3.8577 mL | 9.6443 mL | |
| 10 mM | 0.1929 mL | 0.9644 mL | 1.9289 mL | 4.8222 mL | |
| 15 mM | 0.1286 mL | 0.6430 mL | 1.2859 mL | 3.2148 mL | |
| 20 mM | 0.0964 mL | 0.4822 mL | 0.9644 mL | 2.4111 mL | |
| 25 mM | 0.0772 mL | 0.3858 mL | 0.7715 mL | 1.9289 mL | |
| 30 mM | 0.0643 mL | 0.3215 mL | 0.6430 mL | 1.6074 mL | |
| 40 mM | 0.0482 mL | 0.2411 mL | 0.4822 mL | 1.2055 mL | |
| 50 mM | 0.0386 mL | 0.1929 mL | 0.3858 mL | 0.9644 mL | |
| 60 mM | 0.0321 mL | 0.1607 mL | 0.3215 mL | 0.8037 mL | |
| 80 mM | 0.0241 mL | 0.1206 mL | 0.2411 mL | 0.6028 mL | |
| 100 mM | 0.0193 mL | 0.0964 mL | 0.1929 mL | 0.4822 mL |
Thalidomide-PEG2-C2-NH2 TFA Related Classifications
HY-129703A Related Classifications
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