1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-C3-PEG3-C1-NH2

Thalidomide-O-amido-C3-PEG3-C1-NH2 

Cat. No.: HY-131646
Handling Instructions

Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-amido-C3-PEG3-C1-NH2 Chemical Structure

Thalidomide-O-amido-C3-PEG3-C1-NH2 Chemical Structure

CAS No. : 1799711-29-7

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25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 900 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

Molecular Weight

648.58

Formula

C₂₇H₃₅F₃N₄O₁₁

CAS No.

1799711-29-7

SMILES

O=C(NCCCOCCOCCOCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (308.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5418 mL 7.7091 mL 15.4183 mL
5 mM 0.3084 mL 1.5418 mL 3.0837 mL
10 mM 0.1542 mL 0.7709 mL 1.5418 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (7.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (7.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (7.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide-O-amido-C3-PEG3-C1-NH2E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-O-amido-C3-PEG3-C1-NH2
Cat. No.:
HY-131646
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