CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc
CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc is a cereblon (CRBN) ligand and ligase binding ligand (LBL) used in synthesis of p300 protein degraders, also designated as compound 28f.CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc is tert-butyl (trans-4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methoxy-2-naphthamido)cyclohexyl)carbamate, a CRBN ligand intermediate for synthesis of degrader 28.
For research use only. We do not sell to patients.
- Formula: C27H34N4O6
- Molecular Weight:510.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Cereblon |
In Vitro
CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc (Compound 28f) is an E3 ligase ligand-linker conjugate combining a CRBN ligand and a ligase, and it is used for the synthesis of PROTAC CBP/P300 Degrader-4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 510.58
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Formula C27H34N4O6
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SMILES
O=C1N(CCC(N1)=O)C(C=C2C(N[C@@H](CC3)CC[C@H]3NC(OC(C)(C)C)=O)=O)=C4C(C=CC=C4)=C2OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc Related Classifications
HY-183819 Related Classifications
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