Thalidomide-NH-C2-PEG3-OH
Based on 1 Customer Validation
Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 2140807-23-2
- Formula: C21H27N3O8
- Molecular Weight:449.45
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
Chemical Information
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CAS No. 2140807-23-2
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Appearance Oil
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Molecular Weight 449.45
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Formula C21H27N3O8
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (222.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2249 mL | 11.1247 mL | 22.2494 mL | 55.6235 mL |
| 5 mM | 0.4450 mL | 2.2249 mL | 4.4499 mL | 11.1247 mL | |
| 10 mM | 0.2225 mL | 1.1125 mL | 2.2249 mL | 5.5624 mL | |
| 15 mM | 0.1483 mL | 0.7416 mL | 1.4833 mL | 3.7082 mL | |
| 20 mM | 0.1112 mL | 0.5562 mL | 1.1125 mL | 2.7812 mL | |
| 25 mM | 0.0890 mL | 0.4450 mL | 0.8900 mL | 2.2249 mL | |
| 30 mM | 0.0742 mL | 0.3708 mL | 0.7416 mL | 1.8541 mL | |
| 40 mM | 0.0556 mL | 0.2781 mL | 0.5562 mL | 1.3906 mL | |
| 50 mM | 0.0445 mL | 0.2225 mL | 0.4450 mL | 1.1125 mL | |
| 60 mM | 0.0371 mL | 0.1854 mL | 0.3708 mL | 0.9271 mL | |
| 80 mM | 0.0278 mL | 0.1391 mL | 0.2781 mL | 0.6953 mL | |
| 100 mM | 0.0222 mL | 0.1112 mL | 0.2225 mL | 0.5562 mL |
Thalidomide-NH-C2-PEG3-OH Related Classifications
HY-131308 Related Classifications
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