Thalidomide-5-PEG4-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 95.21%
- CAS No.: 2743434-24-2
- Formula: C21H28ClN3O8
- Molecular Weight:485.92
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2743434-24-2
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Appearance Oil
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Molecular Weight 485.92
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Formula C21H28ClN3O8
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Color Light yellow to yellow
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SMILES
NCCOCCOCCOCCOC1=CC(C(N2C(C3=O)CCC(N3)=O)=O)=C(C=C1)C2=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (205.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0580 mL | 10.2898 mL | 20.5795 mL | 51.4488 mL |
| 5 mM | 0.4116 mL | 2.0580 mL | 4.1159 mL | 10.2898 mL | |
| 10 mM | 0.2058 mL | 1.0290 mL | 2.0580 mL | 5.1449 mL | |
| 15 mM | 0.1372 mL | 0.6860 mL | 1.3720 mL | 3.4299 mL | |
| 20 mM | 0.1029 mL | 0.5145 mL | 1.0290 mL | 2.5724 mL | |
| 25 mM | 0.0823 mL | 0.4116 mL | 0.8232 mL | 2.0580 mL | |
| 30 mM | 0.0686 mL | 0.3430 mL | 0.6860 mL | 1.7150 mL | |
| 40 mM | 0.0514 mL | 0.2572 mL | 0.5145 mL | 1.2862 mL | |
| 50 mM | 0.0412 mL | 0.2058 mL | 0.4116 mL | 1.0290 mL | |
| 60 mM | 0.0343 mL | 0.1715 mL | 0.3430 mL | 0.8575 mL | |
| 80 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.6431 mL | |
| 100 mM | 0.0206 mL | 0.1029 mL | 0.2058 mL | 0.5145 mL |
Thalidomide-5-PEG4-NH2 hydrochloride Related Classifications
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