2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Glutarimide-Isoindolinone-NH-PEG2-COOH

Glutarimide-Isoindolinone-NH-PEG2-COOH 

Cat. No.: HY-138792 Purity: 98.51%
COA Handling Instructions

Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Glutarimide-Isoindolinone-NH-PEG2-COOH Chemical Structure

Glutarimide-Isoindolinone-NH-PEG2-COOH Chemical Structure

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50 mg USD 1600 In-stock
100 mg USD 2500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1

  • Biological Activity

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  • References

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Description

Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

419.43

Appearance

Oil

Formula

C20H25N3O7
SMILES

O=C1C2=CC=C(C=C2CN1C3C(NC(CC3)=O)=O)NCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 73.33 mg/mL (174.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3842 mL 11.9209 mL 23.8419 mL
5 mM 0.4768 mL 2.3842 mL 4.7684 mL
10 mM 0.2384 mL 1.1921 mL 2.3842 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.75 mg/mL (16.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.75 mg/mL (16.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.5 mg/mL (13.11 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.51%

COA (243 KB) HNMR (290 KB) LCMS (116 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Glutarimide-Isoindolinone-NH-PEG2-COOHE3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Product Name:
Glutarimide-Isoindolinone-NH-PEG2-COOH
Cat. No.:
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