2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-PEG4-azide

Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Thalidomide-O-PEG4-azide Chemical Structure

Thalidomide-O-PEG4-azide Chemical Structure

CAS No. : 2380318-57-8

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25 mg USD 340 In-stock
50 mg USD 560 In-stock
100 mg USD 920 In-stock
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Based on 1 publication(s) in Google Scholar

Thalidomide-O-PEG4-azide Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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  • Purity & Documentation

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Description

Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-O-PEG4-azide Related Antibodies
Molecular Weight

519.50

Formula

C23H29N5O9
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCN=[N+]=[N-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (481.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9249 mL 9.6246 mL 19.2493 mL
5 mM 0.3850 mL 1.9249 mL 3.8499 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9249 mL 9.6246 mL 19.2493 mL 48.1232 mL
5 mM 0.3850 mL 1.9249 mL 3.8499 mL 9.6246 mL
10 mM 0.1925 mL 0.9625 mL 1.9249 mL 4.8123 mL
15 mM 0.1283 mL 0.6416 mL 1.2833 mL 3.2082 mL
20 mM 0.0962 mL 0.4812 mL 0.9625 mL 2.4062 mL
25 mM 0.0770 mL 0.3850 mL 0.7700 mL 1.9249 mL
30 mM 0.0642 mL 0.3208 mL 0.6416 mL 1.6041 mL
40 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2031 mL
50 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9625 mL
60 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8021 mL
80 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6015 mL
100 mM 0.0192 mL 0.0962 mL 0.1925 mL 0.4812 mL
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Thalidomide-O-PEG4-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-PEG4-azide2380318-57-8E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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