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Cat. No.: HY-W934539

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Lenalidomide-amide-C8-Br

Lenalidomide-amide-C8-Br is an E3 ligase CRBN ligand-linker conjugate containing Lenalidomide (HY-A0003) and a linker. Lenalidomide-amide-C8-Br can be used to synthesize PROTAC PI3Kα/δ degrader-1 (HY-182083).

For research use only. We do not sell to patients.

CAS No.: 2580972-35-4
Formula: C₂₂H₂₈BrN₃O₄
Molecular Weight:478.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lenalidomide-amide-C8-Br Chemical Structure

CAS No.: 2580972-35-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target^[1]

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2580972-35-4
Molecular Weight 478.38
Formula C₂₂H₂₈BrN₃O₄
SMILES

O=C1NC(C(CC1)N2C(C3=C(C2)C(NC(CCCCCCCCBr)=O)=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hou Y, et al. Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic Liability. J Med Chem. Published online March 8, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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