(S,R,S)-AHPC-Bromooctanoic acid
(S,R,S)-AHPC-Bromooctanoic acid is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding linker (HY-W007700). (S,R,S)-AHPC-Bromooctanoic acid can serve as VHL (von Hippel-Lindau) ligand to recruit the VHL protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- CAS No.: 2408342-03-8
- Formula: C30H43BrN4O4S
- Molecular Weight:635.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
HIF-1α PROTAC contains two different ligands connected by a linker; one is an E3 ligase ligand ((S,R,S)-AHPC) (HY-125845), and the other is for Ligands of HIF-1α target protein (HIF-1α-IN-10) (HY-179434). PROTAC exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2408342-03-8
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Molecular Weight 635.66
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Formula C30H43BrN4O4S
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SMILES
BrCCCCCCCC(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)=O
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Synonyms
VH032-NH-Bromooctanoic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S,R,S)-AHPC-Bromooctanoic acid Related Classifications
HY-179435 Related Classifications
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