(S,R,S)-AHPC-Bromooctanoic acid  (Synonyms: VH032-NH-Bromooctanoic acid)

(S,R,S)-AHPC-Bromooctanoic acid is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding linker (HY-W007700). (S,R,S)-AHPC-Bromooctanoic acid can serve as VHL (von Hippel-Lindau) ligand to recruit the VHL protein and serve as a key intermediate for the synthesis of complete PROTAC molecules^[1].

HIF-1α PROTAC contains two different ligands connected by a linker; one is an E3 ligase ligand ((S,R,S)-AHPC) (HY-125845), and the other is for Ligands of HIF-1α target protein (HIF-1α-IN-10) (HY-179434). PROTAC exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

635.66

C₃₀H₄₃BrN₄O₄S

2408342-03-8

BrCCCCCCCC(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhu EJ, et al. Design, synthesis and biological evaluation of novel HIF-1α PROTACs degrader as potent anti-cervical cancer agents. Bioorg Med Chem Lett. 2026 Feb 1;131:130443.  [Content Brief]