(S,R,S)-AHPC-C1-NH2 hydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity : 98.08%
- CAS No.: 2361120-26-3
- Formula: C24H34ClN5O4S
- Molecular Weight:524.08
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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VHL |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2361120-26-3
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Appearance Solid
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Molecular Weight 524.08
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Formula C24H34ClN5O4S
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Color Off-white to light yellow
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SMILES
NCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (238.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9081 mL | 9.5405 mL | 19.0811 mL | 47.7026 mL |
| 5 mM | 0.3816 mL | 1.9081 mL | 3.8162 mL | 9.5405 mL | |
| 10 mM | 0.1908 mL | 0.9541 mL | 1.9081 mL | 4.7703 mL | |
| 15 mM | 0.1272 mL | 0.6360 mL | 1.2721 mL | 3.1802 mL | |
| 20 mM | 0.0954 mL | 0.4770 mL | 0.9541 mL | 2.3851 mL | |
| 25 mM | 0.0763 mL | 0.3816 mL | 0.7632 mL | 1.9081 mL | |
| 30 mM | 0.0636 mL | 0.3180 mL | 0.6360 mL | 1.5901 mL | |
| 40 mM | 0.0477 mL | 0.2385 mL | 0.4770 mL | 1.1926 mL | |
| 50 mM | 0.0382 mL | 0.1908 mL | 0.3816 mL | 0.9541 mL | |
| 60 mM | 0.0318 mL | 0.1590 mL | 0.3180 mL | 0.7950 mL | |
| 80 mM | 0.0239 mL | 0.1193 mL | 0.2385 mL | 0.5963 mL | |
| 100 mM | 0.0191 mL | 0.0954 mL | 0.1908 mL | 0.4770 mL |
(S,R,S)-AHPC-C1-NH2 hydrochloride Related Classifications
HY-138861A Related Classifications
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