(S,R,S)-AHPC-C1-NH2 hydrochloride

Name: (S,R,S)-AHPC-C1-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-138861A
Rating: 4.5 (0 reviews)

製品番号: HY-138861A 純度: 98.08%: Data Sheet SDS COA 取扱説明書
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(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

(S,R,S)-AHPC-C1-NH2 hydrochloride 構造式

CAS 番号 : 2361120-26-3

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 77	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 77	在庫あり	Estimated Time of Arrival: December 31
Solid
25 mg	$70	在庫あり	Estimated Time of Arrival: December 31
50 mg	$115	在庫あり	Estimated Time of Arrival: December 31
100 mg	$180	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-C1-NH2 hydrochloride:

(S,R,S)-AHPC-C1-NH2 お問い合わせ

E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target

VHL

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

524.08

分子式

C₂₄H₃₄ClN₅O₄S

CAS 番号

2361120-26-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

NCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (238.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9081 mL	9.5405 mL	19.0811 mL
5 mM	0.3816 mL	1.9081 mL	3.8162 mL
10 mM	0.1908 mL	0.9541 mL	1.9081 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.08%

Select Batch:

データシート (275 KB) SDS (393 KB)

COA (255 KB) HNMR (280 KB) RP-HPLC (247 KB) LCMS (96 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9081 mL	9.5405 mL	19.0811 mL	47.7026 mL
	5 mM	0.3816 mL	1.9081 mL	3.8162 mL	9.5405 mL
	10 mM	0.1908 mL	0.9541 mL	1.9081 mL	4.7703 mL
	15 mM	0.1272 mL	0.6360 mL	1.2721 mL	3.1802 mL
	20 mM	0.0954 mL	0.4770 mL	0.9541 mL	2.3851 mL
	25 mM	0.0763 mL	0.3816 mL	0.7632 mL	1.9081 mL
	30 mM	0.0636 mL	0.3180 mL	0.6360 mL	1.5901 mL
	40 mM	0.0477 mL	0.2385 mL	0.4770 mL	1.1926 mL
	50 mM	0.0382 mL	0.1908 mL	0.3816 mL	0.9541 mL
	60 mM	0.0318 mL	0.1590 mL	0.3180 mL	0.7950 mL
	80 mM	0.0239 mL	0.1193 mL	0.2385 mL	0.5963 mL
	100 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.4770 mL