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Thalidomide-5-O-CH2-COO(t-Bu)

Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

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  • CAS No.: 2682112-10-1
  • Formula: C19H20N2O7
  • Molecular Weight:388.37
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Thalidomide-5-O-CH2-COO(t-Bu) Chemical Structure
    Thalidomide-5-O-CH2-COO(t-Bu) Chemical Structure
CAS No.: 2682112-10-1
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Use of MCE Products

All E3 Ligase Ligand-Linker Conjugates Isoforms

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    Thalidomide-5-O-CH2-COO(t-Bu) Chemical Structure
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  • Thalidomide-5-O-CH2-COO(t-Bu)