Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2983037-00-7
- Formula: C25H36ClN5O9
- Molecular Weight:586.03
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
|
Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2983037-00-7
-
Appearance Solid
-
Molecular Weight 586.03
-
Formula C25H36ClN5O9
-
Color Light yellow to yellow
-
SMILES
O=C(C(CC1)N2C(C3=CC=CC(NCC(NCCOCCOCCOCCOCCN)=O)=C3C2=O)=O)NC1=O.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (170.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7064 mL | 8.5320 mL | 17.0640 mL | 42.6599 mL |
| 5 mM | 0.3413 mL | 1.7064 mL | 3.4128 mL | 8.5320 mL | |
| 10 mM | 0.1706 mL | 0.8532 mL | 1.7064 mL | 4.2660 mL | |
| 15 mM | 0.1138 mL | 0.5688 mL | 1.1376 mL | 2.8440 mL | |
| 20 mM | 0.0853 mL | 0.4266 mL | 0.8532 mL | 2.1330 mL | |
| 25 mM | 0.0683 mL | 0.3413 mL | 0.6826 mL | 1.7064 mL | |
| 30 mM | 0.0569 mL | 0.2844 mL | 0.5688 mL | 1.4220 mL | |
| 40 mM | 0.0427 mL | 0.2133 mL | 0.4266 mL | 1.0665 mL | |
| 50 mM | 0.0341 mL | 0.1706 mL | 0.3413 mL | 0.8532 mL | |
| 60 mM | 0.0284 mL | 0.1422 mL | 0.2844 mL | 0.7110 mL | |
| 80 mM | 0.0213 mL | 0.1066 mL | 0.2133 mL | 0.5332 mL | |
| 100 mM | 0.0171 mL | 0.0853 mL | 0.1706 mL | 0.4266 mL |
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride Related Classifications
HY-138857A Related Classifications
Powered by Bioz