Pomalidomide-C2-NH2 hydrochloride
Based on 1 Customer Validation
Pomalidomide-C2-NH2 (Cereblon Ligand-Linker Conjugate 15) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 99.32%
- CAS No.: 2305369-00-8
- Formula: C15H17ClN4O4
- Molecular Weight:352.78
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2305369-00-8
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Appearance Solid
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Molecular Weight 352.78
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Formula C15H17ClN4O4
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Color Light yellow to yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCN)=O.[H]Cl
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Synonyms
Cereblon Ligand-Linker Conjugates 15 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (354.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8346 mL | 14.1731 mL | 28.3463 mL | 70.8657 mL |
| 5 mM | 0.5669 mL | 2.8346 mL | 5.6693 mL | 14.1731 mL | |
| 10 mM | 0.2835 mL | 1.4173 mL | 2.8346 mL | 7.0866 mL | |
| 15 mM | 0.1890 mL | 0.9449 mL | 1.8898 mL | 4.7244 mL | |
| 20 mM | 0.1417 mL | 0.7087 mL | 1.4173 mL | 3.5433 mL | |
| 25 mM | 0.1134 mL | 0.5669 mL | 1.1339 mL | 2.8346 mL | |
| 30 mM | 0.0945 mL | 0.4724 mL | 0.9449 mL | 2.3622 mL | |
| 40 mM | 0.0709 mL | 0.3543 mL | 0.7087 mL | 1.7716 mL | |
| 50 mM | 0.0567 mL | 0.2835 mL | 0.5669 mL | 1.4173 mL | |
| 60 mM | 0.0472 mL | 0.2362 mL | 0.4724 mL | 1.1811 mL | |
| 80 mM | 0.0354 mL | 0.1772 mL | 0.3543 mL | 0.8858 mL | |
| 100 mM | 0.0283 mL | 0.1417 mL | 0.2835 mL | 0.7087 mL |
Pomalidomide-C2-NH2 hydrochloride Related Classifications
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