Thalidomide-O-C7-acid
Based on 1 Customer Validation
Thalidomide-O-C7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-C7-acid can be used to synthesize PROTAC.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.55%
- CAS 番号: 2169266-70-8
- 分子式: C21H24N2O7
- 分子量:416.42
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Cereblon |
体外実験
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2169266-70-8
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性状 Solid
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分子量 416.42
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分子式 C21H24N2O7
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Color White to off-white
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SMILES
O=C(O)CCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4014 mL | 12.0071 mL | 24.0142 mL | 60.0355 mL |
| 5 mM | 0.4803 mL | 2.4014 mL | 4.8028 mL | 12.0071 mL | |
| 10 mM | 0.2401 mL | 1.2007 mL | 2.4014 mL | 6.0036 mL | |
| 15 mM | 0.1601 mL | 0.8005 mL | 1.6009 mL | 4.0024 mL | |
| 20 mM | 0.1201 mL | 0.6004 mL | 1.2007 mL | 3.0018 mL | |
| 25 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4014 mL | |
| 30 mM | 0.0800 mL | 0.4002 mL | 0.8005 mL | 2.0012 mL | |
| 40 mM | 0.0600 mL | 0.3002 mL | 0.6004 mL | 1.5009 mL | |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4803 mL | 1.2007 mL | |
| 60 mM | 0.0400 mL | 0.2001 mL | 0.4002 mL | 1.0006 mL | |
| 80 mM | 0.0300 mL | 0.1501 mL | 0.3002 mL | 0.7504 mL | |
| 100 mM | 0.0240 mL | 0.1201 mL | 0.2401 mL | 0.6004 mL |
Thalidomide-O-C7-acid 関連分類
HY-131874 関連分類
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