Thalidomide-O-C7-acid
Based on 1 Customer Validation
Thalidomide-O-C7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-C7-acid can be used to synthesize PROTAC.
For research use only. We do not sell to patients.
- Purity: 98.55%
- CAS No.: 2169266-70-8
- Formula: C21H24N2O7
- Molecular Weight:416.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2169266-70-8
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Appearance Solid
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Molecular Weight 416.42
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Formula C21H24N2O7
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Color White to off-white
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SMILES
O=C(O)CCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4014 mL | 12.0071 mL | 24.0142 mL | 60.0355 mL |
| 5 mM | 0.4803 mL | 2.4014 mL | 4.8028 mL | 12.0071 mL | |
| 10 mM | 0.2401 mL | 1.2007 mL | 2.4014 mL | 6.0036 mL | |
| 15 mM | 0.1601 mL | 0.8005 mL | 1.6009 mL | 4.0024 mL | |
| 20 mM | 0.1201 mL | 0.6004 mL | 1.2007 mL | 3.0018 mL | |
| 25 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4014 mL | |
| 30 mM | 0.0800 mL | 0.4002 mL | 0.8005 mL | 2.0012 mL | |
| 40 mM | 0.0600 mL | 0.3002 mL | 0.6004 mL | 1.5009 mL | |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4803 mL | 1.2007 mL | |
| 60 mM | 0.0400 mL | 0.2001 mL | 0.4002 mL | 1.0006 mL | |
| 80 mM | 0.0300 mL | 0.1501 mL | 0.3002 mL | 0.7504 mL | |
| 100 mM | 0.0240 mL | 0.1201 mL | 0.2401 mL | 0.6004 mL |
Thalidomide-O-C7-acid Related Classifications
HY-131874 Related Classifications
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