1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-NH-C6-NH2 TFA

Thalidomide-NH-C6-NH2 TFA 

Cat. No.: HY-129704A Purity: 99.82%
Handling Instructions

Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-NH-C6-NH2 TFA Chemical Structure

Thalidomide-NH-C6-NH2 TFA Chemical Structure

CAS No. : 2093386-51-5

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Description

Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

486.44

Formula

C₂₁H₂₅F₃N₄O₆

CAS No.

2093386-51-5

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCN)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
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Keywords:

Thalidomide-NH-C6-NH2E3 Ligase Ligand-Linker ConjugateThalidomidePROTACInhibitorinhibitorinhibit

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Product name:
Thalidomide-NH-C6-NH2 TFA
Cat. No.:
HY-129704A
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