2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. E3 Ligase Ligand-linker Conjugate 225

E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732).

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E3 Ligase Ligand-linker Conjugate 225

E3 Ligase Ligand-linker Conjugate 225 Estructura química

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E3 Ligase Ligand-linker Conjugate 225 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Descripciòn

E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732)[1].

IC50 & Target

VHL

 

In Vitro

A PROTAC consists of two distinct ligands linked by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to a target protein. PROTACs harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E3 Ligase Ligand-linker Conjugate 225 Related Antibodies
Peso molecular

679.87

Fòrmula

C32H46FN5O6S2
SMILES

CNCCOCCOCCSC(C)(C)[C@@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)NC(C4(F)CC4)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Referencias
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E3 Ligase Ligand-linker Conjugate 225 Related Classifications

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Keywords:

E3 Ligase Ligand-linker Conjugate 225E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Nombre del producto:
E3 Ligase Ligand-linker Conjugate 225
Cat. No.:
HY-181737
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