E3 Ligase Ligand-linker Conjugate 225
E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732).
For research use only. We do not sell to patients.
- Formula: C32H46FN5O6S2
- Molecular Weight:679.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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VHL |
In Vitro
A PROTAC consists of two distinct ligands linked by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to a target protein. PROTACs harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 679.87
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Formula C32H46FN5O6S2
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SMILES
CNCCOCCOCCSC(C)(C)[C@@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)NC(C4(F)CC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E3 Ligase Ligand-linker Conjugate 225 Related Classifications
HY-181737 Related Classifications
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