1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-PEG3-C2-NH2 TFA

Pomalidomide-PEG3-C2-NH2 TFA (Synonyms: Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA)

Cat. No.: HY-128716A Purity: 99.00%
Handling Instructions

Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG3-C2-NH2 TFA Chemical Structure

Pomalidomide-PEG3-C2-NH2 TFA Chemical Structure

CAS No. : 2414913-97-4

Size Price Stock Quantity
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
1 g USD 3350 In-stock
Estimated Time of Arrival: December 31
2 g USD 4900 Get quote
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

Molecular Weight

562.49

Formula

C₂₃H₂₉F₃N₄O₉

CAS No.

2414913-97-4

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (177.78 mM; Need ultrasonic)

Ethanol : 100 mg/mL (177.78 mM; Need ultrasonic)

H2O : 16.67 mg/mL (29.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7778 mL 8.8890 mL 17.7781 mL
5 mM 0.3556 mL 1.7778 mL 3.5556 mL
10 mM 0.1778 mL 0.8889 mL 1.7778 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.00%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pomalidomide-PEG3-C2-NH2Cereblon Ligand-Linker Conjugates 5E3 ligase Ligand-Linker Conjugates 30E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Pomalidomide-PEG3-C2-NH2 TFA
Cat. No.:
HY-128716A
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