Pomalidomide-PEG3-C2-NH2 TFA
Based on 1 Customer Validation
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 2414913-97-4
- Formula: C23H29F3N4O9
- Molecular Weight:562.49
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-103598
(S,R,S)-AHPC-PEG3-N3
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HY-103601
(S,R,S)-AHPC-PEG4-N3
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HY-103600
(S,R,S)-AHPC-PEG1-N3
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HY-21930
Pomalidomide-PEG4-C-COOH
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
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HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
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HY-103615
Thalidomide-O-amido-C4-N3
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HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
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HY-103606
(S,R,S)-AHPC-PEG6-C4-Cl
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HY-126458
Thalidomide-O-PEG2-propargyl
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HY-103613
Thalidomide-O-amido-C4-NH2 TFA
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HY-41549
Pomalidomide-PEG4-Ph-NH2
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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Cereblon |
Chemical Information
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CAS No. 2414913-97-4
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Appearance Solid-Liquid Mixture
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Molecular Weight 562.49
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Formula C23H29F3N4O9
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Color Light yellow to yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O
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Synonyms
Cereblon Ligand-Linker Conjugates 5 TFA ; E3 ligase Ligand-Linker Conjugates 30 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (177.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 100 mg/mL (177.78 mM; Need ultrasonic)
H2O : 16.67 mg/mL (29.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (59.25 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO / Ethanol | 1 mM | 1.7778 mL | 8.8890 mL | 17.7781 mL | 44.4452 mL |
| 5 mM | 0.3556 mL | 1.7778 mL | 3.5556 mL | 8.8890 mL | |
| 10 mM | 0.1778 mL | 0.8889 mL | 1.7778 mL | 4.4445 mL | |
| 15 mM | 0.1185 mL | 0.5926 mL | 1.1852 mL | 2.9630 mL | |
| 20 mM | 0.0889 mL | 0.4445 mL | 0.8889 mL | 2.2223 mL | |
| 25 mM | 0.0711 mL | 0.3556 mL | 0.7111 mL | 1.7778 mL | |
| DMSO / Ethanol | 30 mM | 0.0593 mL | 0.2963 mL | 0.5926 mL | 1.4815 mL |
| 40 mM | 0.0444 mL | 0.2222 mL | 0.4445 mL | 1.1111 mL | |
| 50 mM | 0.0356 mL | 0.1778 mL | 0.3556 mL | 0.8889 mL | |
| 60 mM | 0.0296 mL | 0.1482 mL | 0.2963 mL | 0.7408 mL | |
| 80 mM | 0.0222 mL | 0.1111 mL | 0.2222 mL | 0.5556 mL | |
| 100 mM | 0.0178 mL | 0.0889 mL | 0.1778 mL | 0.4445 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Pomalidomide-PEG3-C2-NH2 TFA Related Classifications
HY-128716A Related Classifications
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