1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-C8-NH2

Thalidomide-O-amido-C8-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 2; E3 Ligase Ligand-Linker Conjugates 20)

Cat. No.: HY-107439
Handling Instructions

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thalidomide-O-amido-C8-NH2 Chemical Structure

Thalidomide-O-amido-C8-NH2 Chemical Structure

CAS No. : 1950635-15-0

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Description

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cereblon

 

In Vitro

Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[1].

Molecular Weight

458.51

Formula

C₂₃H₃₀N₄O₆

CAS No.

1950635-15-0

SMILES

NCCCCCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Thalidomide-O-amido-C8-NH2Cereblon Ligand-Linker Conjugates 2E3 Ligase Ligand-Linker Conjugates 20E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-O-amido-C8-NH2
Cat. No.:
HY-107439
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