1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-C8-NH2 hydrochloride

Thalidomide-O-amido-C8-NH2 hydrochloride 

Cat. No.: HY-107439A
Handling Instructions

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Structure

Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Structure

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Description

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target

Cereblon

 

In Vitro

Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[1].

Molecular Weight

494.97

Formula

C₂₃H₃₁ClN₄O₆

SMILES

O=C(NCCCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Thalidomide-O-amido-C8-NH2E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product name:
Thalidomide-O-amido-C8-NH2 hydrochloride
Cat. No.:
HY-107439A
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