1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-C3-COOH

Thalidomide-O-amido-C3-COOH (Synonyms: Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15)

Cat. No.: HY-103612 Purity: 99.49%
Handling Instructions

Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-amido-C3-COOH Chemical Structure

Thalidomide-O-amido-C3-COOH Chemical Structure

CAS No. : 2308035-51-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
1 g USD 3350 In-stock
Estimated Time of Arrival: December 31
2 g USD 4900 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugate Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

IC50 & Target

Cereblon

 

Molecular Weight

417.37

Formula

C₁₉H₁₉N₃O₈

CAS No.
SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCC(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 55.5 mg/mL (132.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3960 mL 11.9798 mL 23.9596 mL
5 mM 0.4792 mL 2.3960 mL 4.7919 mL
10 mM 0.2396 mL 1.1980 mL 2.3960 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide-O-amido-C3-COOHCereblon Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 15E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Thalidomide-O-amido-C3-COOH
Cat. No.:
HY-103612
Quantity:
MCE Japan Authorized Agent: