2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-PEG5-alkyne

Thalidomide-O-PEG5-alkyne is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

For research use only. We do not sell to patients.

Thalidomide-O-PEG5-alkyne

Thalidomide-O-PEG5-alkyne Chemical Structure

CAS No. : 2411681-90-6

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Thalidomide-O-PEG5-alkyne Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-O-PEG5-alkyne is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-O-PEG5-alkyne Related Antibodies
Molecular Weight

546.53

Formula

C26H30N2O11
CAS No.
SMILES

O=C(OCCOCCOCCOCCOCC#C)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Thalidomide-O-PEG5-alkyne Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-PEG5-alkyne2411681-90-6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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