1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Thalidomide-Piperazine-Piperidine hydrochloride

Thalidomide-Piperazine-Piperidine hydrochloride 

Cat. No.: HY-138783A Purity: 98.73%
COA Handling Instructions

Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-Piperazine-Piperidine hydrochloride Chemical Structure

Thalidomide-Piperazine-Piperidine hydrochloride Chemical Structure

CAS No. : 2599846-44-1

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5 mg USD 350 In-stock
10 mg USD 580 In-stock
25 mg USD 1100 In-stock
50 mg USD 1700 In-stock
100 mg USD 2600 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.94

Formula

C22H28ClN5O4

CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(C5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (72.15 mM; Need ultrasonic)

DMSO : 3.6 mg/mL (7.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1648 mL 10.8239 mL 21.6478 mL
5 mM 0.4330 mL 2.1648 mL 4.3296 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.1648 mL 10.8239 mL 21.6478 mL 54.1196 mL
5 mM 0.4330 mL 2.1648 mL 4.3296 mL 10.8239 mL
H2O 10 mM 0.2165 mL 1.0824 mL 2.1648 mL 5.4120 mL
15 mM 0.1443 mL 0.7216 mL 1.4432 mL 3.6080 mL
20 mM 0.1082 mL 0.5412 mL 1.0824 mL 2.7060 mL
25 mM 0.0866 mL 0.4330 mL 0.8659 mL 2.1648 mL
30 mM 0.0722 mL 0.3608 mL 0.7216 mL 1.8040 mL
40 mM 0.0541 mL 0.2706 mL 0.5412 mL 1.3530 mL
50 mM 0.0433 mL 0.2165 mL 0.4330 mL 1.0824 mL
60 mM 0.0361 mL 0.1804 mL 0.3608 mL 0.9020 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Thalidomide-Piperazine-Piperidine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Thalidomide-Piperazine-Piperidine hydrochloride
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HY-138783A
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