Thalidomide-Piperazine-Piperidine hydrochloride
Based on 1 Customer Validation
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 98.41%
- CAS No.: 2599846-44-1
- Formula: C22H28ClN5O4
- Molecular Weight:461.94
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2599846-44-1
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Appearance Solid
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Molecular Weight 461.94
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Formula C22H28ClN5O4
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Color Light yellow to green yellow
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SMILES
O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(C5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 33.33 mg/mL (72.15 mM; Need ultrasonic)
DMSO : 3.6 mg/mL (7.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.1648 mL | 10.8239 mL | 21.6478 mL | 54.1196 mL |
| 5 mM | 0.4330 mL | 2.1648 mL | 4.3296 mL | 10.8239 mL | |
| H2O | 10 mM | 0.2165 mL | 1.0824 mL | 2.1648 mL | 5.4120 mL |
| 15 mM | 0.1443 mL | 0.7216 mL | 1.4432 mL | 3.6080 mL | |
| 20 mM | 0.1082 mL | 0.5412 mL | 1.0824 mL | 2.7060 mL | |
| 25 mM | 0.0866 mL | 0.4330 mL | 0.8659 mL | 2.1648 mL | |
| 30 mM | 0.0722 mL | 0.3608 mL | 0.7216 mL | 1.8040 mL | |
| 40 mM | 0.0541 mL | 0.2706 mL | 0.5412 mL | 1.3530 mL | |
| 50 mM | 0.0433 mL | 0.2165 mL | 0.4330 mL | 1.0824 mL | |
| 60 mM | 0.0361 mL | 0.1804 mL | 0.3608 mL | 0.9020 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thalidomide-Piperazine-Piperidine hydrochloride Related Classifications
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